Efficient Synthesis of Disubstituted γ‐ketophosphine Derivatives via P‐hetero‐Michael Addition Reaction of [TBA][P(SiCl3)2] With N‐Aryl Acrylamides

• Published in: Chemistry : a European journal Vol. 31; no. 44; pp. e202501462 - n/a
• Main Authors: Chai, Yao, Tian, Ya‐Ling, Jia, Jin‐Hong, Wang, Xi‐Cun, Quan, Zheng‐Jun
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 07.08.2025
• Subjects: [TBA][P(SiCl3)2]; Aromatic compounds; Michael reaction; N‐(aryl)acrylamide; Synthesis; γ‐ketophosphine; [TBA][P(SiCl3)2]; N‐(aryl)acrylamide; γ‐ketophosphine
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.202501462

In this paper, an efficient synthesis of disubstituted (γ‐ketophosphine derivatives from [TBA][P(SiCl₃)₂] and N‐(aryl)acrylamides through P‐hetero‐Michael addition reaction has been successfully achieved. This achievement provides a new, and efficient approach for the preparation of γ‐ketophosphine derivatives. In this research, we have successfully achieved the efficient synthesis of disubstituted γ‐ketophosphine derivatives through the reaction between [TBA][P(SiCl3)2] and N‐(aryl)acrylamides. This strategy utilizes the active low‐valence [TBA][P(SiCl3)2] prepared from phosphoric acid as the phosphorus source, offering a novel, cost‐effective, and highly efficient approach for the preparation of γ‐ketophosphine derivatives with unique biological activities.