Evaluation of antinociceptive, anti-inflammatory and anxiolytic activities of methanolic extract of Terminalia citrina leaves

To investigate the antinociceptive, anti-inflammatory and anxiolytic effects of methanolic extracts of Terminalia citrina (T. citrina) leaves (Family: Combretaceae). The antinociceptive activity was evaluated by acetic acid induced writhing method and radiant heat tail flick method while anti-inflam...

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Bibliographic Details
Published inAsian Pacific journal of tropical disease Vol. 5; pp. S137 - S141
Main Authors Das, Narhari, Goshwami, Durajan, Hasan, Md. Sharif, Mahmud, Zobaer Al, Raihan, Sheikh Zahir, Sultan, Md. Zakir
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2015
Subjects
Anti-inflammatory activity
Antinociceptive activity
Elevated plus maze
Tail flick
Terminalia citrina
Antinociceptive activity
Terminalia citrina
Anti-inflammatory activity
Tail flick
Elevated plus maze
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Summary:To investigate the antinociceptive, anti-inflammatory and anxiolytic effects of methanolic extracts of Terminalia citrina (T. citrina) leaves (Family: Combretaceae). The antinociceptive activity was evaluated by acetic acid induced writhing method and radiant heat tail flick method while anti-inflammatory activity was evaluated by human red blood cell membrane stabilization method and anxiolytic activity by elevated plus maze model. The methanolic extract of T. citrina leaves showed significant antinociceptive, anti-inflammatory and anxiolytic effects in dose dependent manner compared to their respective standard drugs. The present study demonstrated that T. citrina possesses antinociceptive, anti-inflammatory and anxiolytic effects.
ISSN:2222-1808
2222-1808
DOI:10.1016/S2222-1808(15)60875-1