Characterization of heme coordination structure in heme-DNA complex possessing gaseous molecule as an exogenous ligand

Abstract We have previously demonstrated that heme, iron(III)-protoporphyrin IX complex, and a parallel-quadruplex DNA assembled from d(TTAGGG) form a stable coordination complex called "heme-DNA complex". The heme-DNA complex exhibits a variety of spectroscopic characteristics remarkably...

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Published inNucleic Acids Symposium Series Vol. 53; no. 1; pp. 241 - 242
Main Authors Saito, Kaori, Nakano, Yusuke, Tai, Hulin, Nagatomo, Shigenori, Hemmi, Hikaru, Mita, Hajime, Yamamoto, Yasuhiko
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.09.2009
Subjects
Carbon Monoxide - chemistry
DNA - chemistry
G-Quadruplexes
Gases - chemistry
Heme - chemistry
Ligands
Nuclear Magnetic Resonance, Biomolecular
Oxygen - chemistry
Protoporphyrins - chemistry
Spectrum Analysis
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Summary:Abstract We have previously demonstrated that heme, iron(III)-protoporphyrin IX complex, and a parallel-quadruplex DNA assembled from d(TTAGGG) form a stable coordination complex called "heme-DNA complex". The heme-DNA complex exhibits a variety of spectroscopic characteristics remarkably similar to those of met-form of myoglobin, oxygen-binding hemoprotein, reflecting that the heme environments in the two systems are highly alike to each other. In a course of our effort toward exploring functional properties of the heme-DNA complex, we have investigated binding of gaseous molecules such as CO and O2 to the heme-DNA complex. The present study revealed that the heme-DNA complex exhibits ability to accommodate these molecules as exogenous ligands.
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ISSN:0261-3166
1746-8272
DOI:10.1093/nass/nrp121