Primary resistance mutations to fusion inhibitors and polymorphisms in gp41 sequences of HIV-1 non-B subtypes and recombinants

• Published in: AIDS (London) Vol. 17; no. 7; pp. 1083 - 1086
• Main Authors: VILLAHERMOSA, Maria L, PEREZ-ALVAREZ, Lucia, CARMONA, Rocio, CUEVAS, Maria T, THOMSON, Migue M, MEDRANO, Leandro, VAZQUEZ DE PARGA, Elena, DELGADO, Elena, PEDREIRA, José Domingo, NAJERA, Rafael
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 02.05.2003
• Subjects: AIDS/HIV; Anti-HIV Agents - therapeutic use; Biological and medical sciences; Drug Resistance, Viral - genetics; Enfuvirtide; HIV Envelope Protein gp41 - genetics; HIV Envelope Protein gp41 - therapeutic use; HIV Fusion Inhibitors - therapeutic use; HIV Infections - genetics; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Mutation - genetics; Peptide Fragments - therapeutic use; Polymorphism, Genetic; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Europe; Spain; Immunopathology; Typing; HIV-1 virus; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Resistance; Microbiological investigation; Viral disease; Antiviral; Inhibitor; Human immunodeficiency virus; Mutation; Subtype; Polymorphism
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/00002030-200305020-00020

Primary resistance mutations to fusion inhibitors and polymorphisms in gp41 sequences of non-B subtypes and recombinant HIV-1 isolates were analysed. L91H to RPR103611 was detected in one DGpol/Denv/Dgp41 recombinant; L9F and K144R, rarely reported previously, were frequent in the B region of CRF14_BG recombinants. V194I and V318A, not described in the G subtype, were detected in the G region of BG recombinants and in G subtype viruses that also show the rare mutations T115L, M118V and K90R.