The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 49; p. e2305779120
• Main Authors: Turner, Cortney A., Khalil, Huzefa, Murphy-Weinberg, Virginia, Hagenauer, Megan H., Gates, Linda, Tang, Yu, Weinberg, Lauren, Grysko, Robert, Floran-Garduno, Leonor, Dokas, Thomas, Samaniego, Catherine, Zhao, Zhuo, Fang, Yu, Sen, Srijan, Lopez, Juan F., Watson, Stanley J., Akil, Huda
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 05.12.2023
• Series: The Neurobiology of Stress: Vulnerability, Resilience, and Major Depression
• Subjects: Affect; Anxiety; Anxiety - epidemiology; Anxiety - genetics; Anxiety Disorders; Biological Sciences; COVID-19; COVID-19 - epidemiology; COVID-19 - genetics; Depression - epidemiology; Depression - genetics; Exercise; Female; Females; Humans; Mental depression; Pandemics; Physical activity; Polygenic inheritance; Psychological factors; Resilience; Risk; Sex differences; Sleep; students; polygenic risk; depression

Using a longitudinal approach, we sought to define the interplay between genetic and nongenetic factors in shaping vulnerability or resilience to COVID-19 pandemic stress, as indexed by the emergence of symptoms of depression and/or anxiety. University of Michigan freshmen were characterized at base...