Phospholipid-detergent systems: effects of polysorbates on the release of liposomal caffeine

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 53; no. 10; pp. 650 - 654
• Main Authors: Fadda, Anna Maria, Baroli, Bianca Maria, Maccioni, Anna Maria, Sinico, Chiara, Valenti, Donatella, Alhaique, Franco
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.11.1998; Elsevier Science
• Subjects: Biological and medical sciences; Diffusion; General pharmacology; Liposomes; Medical sciences; Mixed micelles; MLV; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Sustained release; SUV; Mixed micelles; Sustained release; Liposomes; Diffusion; SUV; MLV; Multilayer; Controlled release form; Liposome; Mixed micelle; Phospholipid; Lipophily; Polymer; Drug adjuvant; Surfactant; Complex lipid; Lamellar structure; Concentration effect; Dosage form; Polysorbate

It is well known that surfactants are capable of interacting with phospholipid vesicles leading to different aggregated structures and finally to mixed micellar systems. By means of diffusion experiments with Valia-Chien cells the effect of different vesicular structures (MLV and SUV) and that of th...