Phospholipid-detergent systems: effects of polysorbates on the release of liposomal caffeine

It is well known that surfactants are capable of interacting with phospholipid vesicles leading to different aggregated structures and finally to mixed micellar systems. By means of diffusion experiments with Valia-Chien cells the effect of different vesicular structures (MLV and SUV) and that of th...

Full description

Saved in:
Bibliographic Details
Published inFarmaco (Società chimica italiana : 1989) Vol. 53; no. 10; pp. 650 - 654
Main Authors Fadda, Anna Maria, Baroli, Bianca Maria, Maccioni, Anna Maria, Sinico, Chiara, Valenti, Donatella, Alhaique, Franco
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier SAS 01.11.1998
Elsevier Science
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:It is well known that surfactants are capable of interacting with phospholipid vesicles leading to different aggregated structures and finally to mixed micellar systems. By means of diffusion experiments with Valia-Chien cells the effect of different vesicular structures (MLV and SUV) and that of three polysorbates on the release of a model drug (caffeine) from various vesicle formulations was studied. Obtained results indicate that a remarkable delayed/sustained caffeine release is obtained only with the MLV preparations and that the presence of increasing surfactant concentrations initially leads to a further decrease of drug delivery rate and then to a faster release that reaches a maximum when only mixed micelles are present. The variation of the observed effects with the different tested surfactants, in relation to their lipophilicity (HLB values), is also discussed.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(98)00081-0