ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS

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Published in	European journal of medicinal chemistry Vol. 30; pp. 201s - 214s
Main Authors	Kalish, Vincent, Kaldor, Stephen, Shetty, Bhasker, Tatlock, John, Davies, Jay, Hammond, Marius, Dressman, Bruce, Fritz, James, Appelt, Krzysztof, Reich, Siegfried, Musick, Linda, Wu, Bor-wen, Su, Ken
Format	Journal Article Conference Proceeding
Language	English
Published	Oxford Elsevier Masson SAS 1995 Elsevier
Subjects	AG1343 AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences HIV protease inhibitors Medical sciences Pharmacology. Drug treatments structure-based drug design structure-based drug design AIDS AG1343 HIV protease inhibitors Organic hydroxysulfide Isoquinoline derivatives Enzyme Oral administration Retroviridae Enzyme inhibitor Bioavailability Modeling Virus Structure activity relation Animal Molecular model Phenols Hydrolases Lentivirinae Antiviral Human immunodeficiency virus Proteinases Crystalline structure
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Author	Musick, Linda Fritz, James Hammond, Marius Shetty, Bhasker Tatlock, John Dressman, Bruce Wu, Bor-wen Kalish, Vincent Davies, Jay Appelt, Krzysztof Su, Ken Kaldor, Stephen Reich, Siegfried
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Cites_doi	10.1126/science.2548279 10.1073/pnas.85.13.4686 10.1016/0092-8674(89)90873-8 10.1126/science.2183354 10.1126/science.2405486 10.1021/jm00111a001 10.1021/jm00094a024 10.1126/science.6200936 10.1021/jm00112a001 10.1021/jm00054a014 10.1089/aid.1992.8.153 10.1128/jvi.63.6.2550-2556.1989 10.1126/science.6206563 10.1021/jm00038a005 10.1021/jm00172a002 10.1016/S0960-894X(01)80367-X 10.1073/pnas.86.15.5781 10.1021/jm00034a016
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Keywords	structure-based drug design AIDS AG1343 HIV protease inhibitors Organic hydroxysulfide Isoquinoline derivatives Enzyme Oral administration Retroviridae Enzyme inhibitor Bioavailability Modeling Virus Structure activity relation Animal Molecular model Phenols Hydrolases Lentivirinae Antiviral Human immunodeficiency virus Proteinases Crystalline structure
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SubjectTerms	AG1343 AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences HIV protease inhibitors Medical sciences Pharmacology. Drug treatments structure-based drug design
Title	ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS
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