ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS

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Bibliographic Details
Published inEuropean journal of medicinal chemistry Vol. 30; pp. 201s - 214s
Main Authors Kalish, Vincent, Kaldor, Stephen, Shetty, Bhasker, Tatlock, John, Davies, Jay, Hammond, Marius, Dressman, Bruce, Fritz, James, Appelt, Krzysztof, Reich, Siegfried, Musick, Linda, Wu, Bor-wen, Su, Ken
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford Elsevier Masson SAS 1995
Elsevier
Subjects
AG1343
AIDS
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
HIV protease inhibitors
Medical sciences
Pharmacology. Drug treatments
structure-based drug design
structure-based drug design
AIDS
AG1343
HIV protease inhibitors
Organic hydroxysulfide
Isoquinoline derivatives
Enzyme
Oral administration
Retroviridae
Enzyme inhibitor
Bioavailability
Modeling
Virus
Structure activity relation
Animal
Molecular model
Phenols
Hydrolases
Lentivirinae
Antiviral
Human immunodeficiency virus
Proteinases
Crystalline structure
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ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(23)00125-3