Oligonucleotides derived from 5-(1-propynyl)-2′- O-allyl-uridine and 5-(1-propynyl)-2′- O-allyl-cytidine: Synthesis and RNA duplex formation

The protected nucleoside analogs of 5-(1-propynyl)-2′- O-allyl-uridine and 5-(1-propynyl)-2′- O-allyl-cytidine are described. Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA. The protected nucleoside analogs of 5-(1-propynyl)-2′- O-al...

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Bibliographic Details
Published inTetrahedron letters Vol. 34; no. 6; pp. 1003 - 1006
Main Authors Froehler, Brian C., Jones, Robert J., Cao, Xiaodong, Terhorst, Terry J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 05.02.1993
Elsevier
Subjects
Carbohydrates. Nucleosides and nucleotides
Chemistry
Chemistry, Organic
Exact sciences and technology
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
ANTISENSE OLIGONUCLEOTIDES
U2 SNRNP
2'-OME RNA
Molecular hybridization
Oligoribonucleotide
Single stranded RNA
Ribonucleoside
Pyrimidine nucleoside
Ribonucleotide
Duplex
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Summary:The protected nucleoside analogs of 5-(1-propynyl)-2′- O-allyl-uridine and 5-(1-propynyl)-2′- O-allyl-cytidine are described. Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA. The protected nucleoside analogs of 5-(1-propynyl)-2′- O-allyl-uridine and 5-(1-propynyl)-2′- O-allyl-cytidine are described. Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)77476-4