Kinetic determination of pKa in 2′-hydroxychalcones

A kinetic model that enables the determination of pKa of 2′(OH)-chalcone in 60% (w/w) ethanol-water, 32°C, pH 9–10 and ionic strength 0.001 is developed. Experimental data are obtained by UV/VIS and HPLC techniques. C:2′-Hydroxychalcone; F: Flavanone; E: Enol; Ka C, K R and K EF: Acid Dissociation,...

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Bibliographic Details
Published inTetrahedron letters Vol. 34; no. 29; pp. 4615 - 4618
Main Authors Blanco, Sonia F., Debattista, Nora B., Luco, Juan M., Ferretti, Ferdinando H.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 03.09.1993
Elsevier
Subjects
Chemistry
Exact sciences and technology
General and physical chemistry
Solution properties
Solutions
Ethanol
Basic solution
Theoretical study
Dissociation constant
Experimental study
Ketone
Chemical equilibrium
Kinetic model
Organic solvent
Cyclohexane
Benzenic compound
Alkalinity
Aqueous solution
Ethylenic compound
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Summary:A kinetic model that enables the determination of pKa of 2′(OH)-chalcone in 60% (w/w) ethanol-water, 32°C, pH 9–10 and ionic strength 0.001 is developed. Experimental data are obtained by UV/VIS and HPLC techniques. C:2′-Hydroxychalcone; F: Flavanone; E: Enol; Ka C, K R and K EF: Acid Dissociation, Partition and Enolization Constants; cy: cyclohexane; ol-w: ethanol-water 60% w/w
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)60638-X