No Clinical Evidence for Protective Effects of Calcium-Channel Blockers against Acute Renal Failure

To the Editor: Calcium-channel blockers, specifically verapamil, have been shown in animal studies to protect the kidneys against long-term damage after an ischemic insult consisting of an intra-arterial infusion of norepinephrine. 1 Similar studies have demonstrated protective effects in cases of c...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 313; no. 23; pp. 1477 - 1478
Main Authors Hull, R W, Hasbargen, J A
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 05.12.1985
Subjects
Acute Kidney Injury - prevention & control
Calcium Channel Blockers - therapeutic use
Cardiac Surgical Procedures
Humans
Postoperative Complications - prevention & control
Premedication
Retrospective Studies
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Summary:To the Editor: Calcium-channel blockers, specifically verapamil, have been shown in animal studies to protect the kidneys against long-term damage after an ischemic insult consisting of an intra-arterial infusion of norepinephrine. 1 Similar studies have demonstrated protective effects in cases of cold ischemia as well as ischemia due to acute vascular insufficiency. 2 , 3 We conducted a retrospective study looking for the same protective effect in human beings. We analyzed 64 patients who had undergone either coronary artery bypass or valve replacement surgery within the preceding six months; 15 patients were excluded because records of perioperative death were inadequate. The patients were divided . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198512053132313