THE HOURLY EXCRETION OF STEROIDS AFTER A SHORT INTRAVENOUS INFUSION OF ACTH

The hourly excretion of total 17-oxosteroids, total 17-hydroxycorticosteroids, dehydro epi androsterone, pregnanetriol and pregnanediol by six normal males has been measured before and after a short intravenous infusion of adrenocorticotrophic hormone (ACTH). The peak, in the amounts of the various...

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Bibliographic Details
Published inJournal of endocrinology Vol. 19; no. 4; pp. 389 - 397
Main Authors FOTHERBY, K, STRONG, J A
Format Journal Article
LanguageEnglish
Published England BioScientifica 01.12.1959
Subjects
Adrenal Cortex Hormones - urine
Adrenocorticotropic Hormone - pharmacology
Biological Transport
Humans
Infusions, Intravenous
Old Medline
Steroids
ADRENAL CORTEX HORMONES/urine
CORTICOTROPIN/pharmacology
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Summary:The hourly excretion of total 17-oxosteroids, total 17-hydroxycorticosteroids, dehydro epi androsterone, pregnanetriol and pregnanediol by six normal males has been measured before and after a short intravenous infusion of adrenocorticotrophic hormone (ACTH). The peak, in the amounts of the various steroids excreted, occurred 3–4 hr after the commencement of the infusion, and within 6 hr the steroids, produced as a result of the ACTH stimulation, were completely excreted. On most days the subjects excreted quite large amounts of steroids during the period 6·30 a.m. to 10 a.m. The diurnal variation, however, was often obscured by sudden changes in the amounts of steroids excreted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0190389