Prophylaxis against Leptospirosis with Doxycycline

To the Editor: The excellent article by Takafuji et al. (Feb. 23 issue)* fails to discuss one argument: If doxycycline were used as a prophylactic agent against leptospirosis, increasing resistance of various microorganisms that are now still sensitive to tetracyclines would certainly result in thes...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 311; no. 1; p. 54
Main Author Krick, W K
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 05.07.1984
Subjects
Doxycycline - therapeutic use
Humans
Leptospirosis - prevention & control
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Summary:To the Editor: The excellent article by Takafuji et al. (Feb. 23 issue)* fails to discuss one argument: If doxycycline were used as a prophylactic agent against leptospirosis, increasing resistance of various microorganisms that are now still sensitive to tetracyclines would certainly result in these areas. I think that the relatively inexpensive tetracyclines, important drugs in many parts of the world, should be saved for therapeutic use. One might wonder whether we should risk selecting resistant strains for the sake of shortening the discomfort of traveler's diarrhea or decreasing the incidence of leptospirosis in the studied group, in which, as . . . No extract is available for articles shorter than 400 words.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198407053110114