VIP and the Pancreatic Cholera Syndrome

To the Editor: Kane et al. reported that a 10-hour intravenous infusion of porcine vasoactive intestinal polypeptide (VIP) reproduced the symptoms of the pancreatic cholera syndrome in five healthy, nonfasting subjects (Dec. 15 issue). 1 Profuse watery diarrhea, accompanied by hyperchloremic acidosi...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 310; no. 22; pp. 1465 - 1466
Main Authors Verdin, E M, Green, Jr, F W
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 31.05.1984
Subjects
Adenoma, Islet Cell - complications
Body Water - secretion
Diarrhea - physiopathology
Humans
Pancreatic Neoplasms - complications
Vasoactive Intestinal Peptide - physiology
Online AccessGet full text

Cover

More Information
Summary:To the Editor: Kane et al. reported that a 10-hour intravenous infusion of porcine vasoactive intestinal polypeptide (VIP) reproduced the symptoms of the pancreatic cholera syndrome in five healthy, nonfasting subjects (Dec. 15 issue). 1 Profuse watery diarrhea, accompanied by hyperchloremic acidosis, occurred in all subjects within an average of 4.3 hours after the start of the infusion and rapidly resolved when the infusion was terminated. Controversy exists concerning the role of VIP in the pathogenesis of pancreatic cholera. Previous attempts to reproduce the syndrome by means of a short-term (one-hour) infusion of VIP have failed. 2 Similarly, jejunal-perfusion studies have failed . . . No extract is available for articles shorter than 400 words.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198405313102222