Pure, homo-bifunctional poly(ethylene glycol) orthogonally protected: synthesis and characterisation

New orthogonal reversible protections have been introduced on high-molecular weight, di-hydroxy PEGs. The introduction on the reaction intermediates of a removable carboxy group allows an efficient purification from all the undesired polymeric derivatives. A final, pure high-molecular weight DMT-PEG...

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Bibliographic Details
Published inReactive & functional polymers Vol. 48; no. 1; pp. 119 - 128
Main Authors Drioli, Sara, Benedetti, Fabio, Bonora, Gian Maria
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 02.05.2001
Elsevier Science
Subjects
Applied sciences
Chemical modifications
Chemical reactions and properties
Exact sciences and technology
Mass spectrometry
NMR
Organic polymers
Physicochemistry of polymers
Poly(ethylene glycol)
Protection
Purification
NMR
Purification
Protection
Mass spectrometry
Poly(ethylene glycol)
Ethylene oxide polymer
Chemical modification
Telechelic polymer
Carboxylation
Hydroxyl group
Chemical protection
Physical separation
Carboxyl group
Organic anhydride
Experimental study
Alkylation
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Summary:New orthogonal reversible protections have been introduced on high-molecular weight, di-hydroxy PEGs. The introduction on the reaction intermediates of a removable carboxy group allows an efficient purification from all the undesired polymeric derivatives. A final, pure high-molecular weight DMT-PEG-Fmoc has been obtained.
ISSN:1381-5148
DOI:10.1016/S1381-5148(01)00044-X