Referral odyssey plot to visualize causes of surgical delay in mesial temporal lobe epilepsy with hippocampal sclerosis

• Published in: Epilepsy & behavior Vol. 147; p. 109434
• Main Authors: Konomatsu, Kazutoshi, Kakisaka, Yosuke, Ishida, Makoto, Soga, Temma, Ukishiro, Kazushi, Osawa, Shin-ichiro, Jin, Kazutaka, Aoki, Masashi, Nakasato, Nobukazu
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2023
• Subjects: Diagnostic odyssey plot; Epilepsy surgery; Epileptologists; Non-epileptologists; Referral delay; Non-epileptologists; MR; EEG; Referral delay; HS; IQR; Epilepsy surgery; EMU; FBTCS; mTLE; ADEM; FIAS; Diagnostic odyssey plot; FAS; Epileptologists
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2023.109434

•The odyssey plot visualized the referral process and the cause of the surgical delay.•Non-epileptologist referral delay was the most serious cause of overall delay.•Patient delay was the longest in cases developed with -focal-aware seizures (FAS).•Non-epileptologists overlooked FAS in 82% and hippocampal sclerosis (HS) in 86%. The “odyssey plot” was used to visualize referral delays in epilepsy surgery. Participants were 36 patients (19 males; 13–67 years, median 27 years) with mesial temporal lobe epilepsy with hippocampal sclerosis (HS) who underwent resection surgery. The “referral odyssey plot” included five clinical episodes: seizure onset (T1), first visits to a non-epileptologist (T2) and to an epileptologist (T3), first admission to our epilepsy monitoring unit (EMU) (T4), and resection surgery (T5). For each patient, we identified the first seizure type: the physician who first diagnosed focal aware seizure (FAS), focal impaired awareness seizure (FIAS), focal to bilateral tonic-clonic seizure (FBTCS), and radiologically suspected HS. Within the overall delay (T1-T5, median 18 years; interquartile range [IQR] 14), non-epileptologist’s delay (T2-T3, 11.5 years; IQR 12.25) was far (p < 0.0001) longer than patient’s (T1-T2, 0 year; IQR 2.25), epileptologist’s (T3-T4, 1 year; IQR 4), or after-EMU delay (T4-T5, 1 year; IQR 1). FAS onset cases had significantly longer T1-T2 (N = 5, median 7 years; IQR 6) than FIAS (N = 22, 0 year; IQR 1, p < 0.005) or FBTCS onset cases (N = 9, 0 year; IQR 0, p < 0.001). FAS was correctly diagnosed first by non-epileptologists in 17.9%, by out-patient epileptologists in 35.7%, and at the EMU in 46.4%. FIAS was correctly diagnosed first by non-epileptologists in 94.4% and by out-patient epileptologists in 5.6%. Non-epileptologists diagnosed FBTCS in all cases. HS was diagnosed by non-epileptologists in 13.9%, by out-patient epileptologists in 47.2%, and at the EMU in 38.9%. Early referral to epileptologists is most critical for early surgery. Early utilization of the EMU is highly recommended because FAS is often overlooked by outpatient epileptologists. The odyssey plot will be useful to improve the healthcare system for other types of epilepsy.