Regio and enantioselective synthesis of 4-carbomethoxymethyl-1,4 dihydropyridines

Regio and enantioselective 1,4 addition of ethoxyvinyl copper reagent on a pyridine bearing in position 3 a chiral aminal is described. This reaction allows the synthesis of various chiral N-acyl-4-methoxymethyl-1,4-dihydropyridines. Graphic

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 35; no. 30; pp. 5433 - 5436
Main Authors Raussou, Sabine, Gosmini, Romain, Mangeney, Pierre, Alexakis, Alexandre, Commerçon, Monique
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 25.07.1994
Elsevier
Subjects
Chemistry
Chemistry, Organic
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
SALTS
DERIVATIVES
REGIOSELECTIVE ADDITION
Aldehydoester
Enantioselectivity
Regioselectivity
Copper Organic compounds
Nitrogen heterocycle
Six membered ring
Addition reaction
Carboxamide
Enaldehyde
Vinylation
Acylation
Online AccessGet full text

Cover

More Information
Summary:Regio and enantioselective 1,4 addition of ethoxyvinyl copper reagent on a pyridine bearing in position 3 a chiral aminal is described. This reaction allows the synthesis of various chiral N-acyl-4-methoxymethyl-1,4-dihydropyridines. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)73518-0