Synthesis of chiral succinates via Pd( 0) catalyzed carbonylation/asymmetric hydrogenation sequence

We report a novel 4 step synthesis of chiral trisubstituted succinic acid derivatives utilizing carbonylation of a vinyl triflate followed by catalytic asymmetric hydrogenation to yield the title compounds. We report a novel 4 step synthesis of chiral trisubstituted succinic acid derivatives utilizi...

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Bibliographic Details
Published inTetrahedron letters Vol. 35; no. 6; pp. 835 - 838
Main Authors Freskos, John N., Laneman, Scott A., Reilly, Melissa L., Ripin, David H.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 1994
Elsevier
Subjects
Aliphatic compounds
Chemistry
Chemistry, Organic
Exact sciences and technology
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
Carbonylation
Catalytic reaction
Aliphatic compound
Asymmetric reaction
Dicarboxylic acid
Methylation
Hydrogenation
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Summary:We report a novel 4 step synthesis of chiral trisubstituted succinic acid derivatives utilizing carbonylation of a vinyl triflate followed by catalytic asymmetric hydrogenation to yield the title compounds. We report a novel 4 step synthesis of chiral trisubstituted succinic acid derivatives utilizing carbonylation of a vinyl triflate followed by catalytic asymmetric hydrogenation to yield the title compounds
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)75976-4