A concise and enantioselective synthesis of novel HIV-1 protease transition state mimics

Novel HIV-1 protease inhibitors have been prepared in a enantioselective manner via an Evans asymmetric aldol, Claisen rearrangement and iodolactonizat Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 34; no. 12; pp. 1851 - 1854
Main Authors Dorsey, Bruce D., Plzak, Kevin J., Ball, Richard G.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.03.1993
Elsevier
Subjects
Aliphatic compounds
Chemistry
Chemistry, Organic
Condensed matter: structure, mechanical and thermal properties
Exact sciences and technology
Heterocyclic compounds
Organic chemistry
Organic compounds
Physical Sciences
Physics
Preparations and properties
Science & Technology
Structure of solids and liquids; crystallography
Structure of specific crystalline solids
AIDS
CLAISEN REARRANGEMENT
VIRUS
Molecular structure
Asymmetric synthesis
Aliphatic compound
Hydroxyamide
Ketol
Enzyme inhibitor
Experimental study
X ray diffraction
Aldol condensation
Crystalline structure
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Summary:Novel HIV-1 protease inhibitors have been prepared in a enantioselective manner via an Evans asymmetric aldol, Claisen rearrangement and iodolactonizat Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)91945-2