Lack of effect of dietary supplements of glucuronic acid and glucuronolactone on longevity of the rat

• Published in: Nutrition research (New York, N.Y.) Vol. 7; no. 6; pp. 683 - 688
• Main Authors: Ahrens, R.A., Douglass, L.W., Flynn, M.M., Ward, G.M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.1987; Elsevier Science
• Subjects: BetaGlucuronidase Inhibitors; Biological and medical sciences; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Glucuronic Acid; Glucuronolactone; Longevity; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Glucuronolactone; BetaGlucuronidase Inhibitors; Glucuronic Acid; Longevity; Vertebrata; Glucuronic acid; Mammalia; Rat; Food intake; β-D-Glucuronidase; Rodentia; Enzyme inhibitor
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(87)80063-5

The hypothesis tested was that supplementing the diet of the year-old rats with 125 or 250 mg/d of glucuronic acid or 125 mg/d of glucuronolactone (B-glucuronidase inhibitors) would increase longevity. One hundred male rats, 330 days old of the Sprague-Dawley (DVB:SDD) strain were divided into four groups of 25 animals each. All animals were given pelleted stock diet ad libitum for as long as they lived. The drinking fluid was the independent variable. After 30 days on tap water for all 100 rats, each group received one of the following daily treatments until deathday: 1) tap water (control); 2) 0.23% (w/v) glucuronic acid (125 mg/day); 3) 0.46% (w/v) glucuronic acid (250 mg/d); or 4) 0.23% (w/v) glucuronolactone (125 mg/d). Fluid intake was measured and did not differ between treatment groups. The dependent variables were deathday, weight at death and cause of death, as determined by autopsy. There were no significant differences between treatment groups in any of the dependent variables. The hypothesis was rejected.