Small nucleolar RNA

The review considers small nucleolar RNAs (snoRNAs), an abundant group of non-protein-coding RNAs. In association with proteins, snoRNAs determine the two most common nucleotide modifications in rRNA and some other cell RNAs: 2'-O-methylation of ribose and pseudouridylation. In addition, snoRNA...

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Bibliographic Details
Published inMolecular biology (New York) Vol. 41; no. 2; pp. 214 - 226
Main Authors Makarova, JA, Kramerov, DA
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.04.2007
Subjects
Ribonucleic acid
RNA
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Summary:The review considers small nucleolar RNAs (snoRNAs), an abundant group of non-protein-coding RNAs. In association with proteins, snoRNAs determine the two most common nucleotide modifications in rRNA and some other cell RNAs: 2'-O-methylation of ribose and pseudouridylation. In addition, snoRNAs are involved in pre-mRNA cleavage and the telomerase function. Almost all snoRNAs fall into two families, C/D and H/ACA, distinguished by conserved sequence boxes. Although the proteins of C/D and H/ACA snoRNPs have homologous regions, these snoRNPs are assembled differently. The RNA components of RNases P and MRP are also classed with snoRNAs. Another problem considered is the structure and function of small RNAs from Cajal bodies (small organelles associated with the nucleoli), which are similar to snoRNAs.
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ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893307020045