Muscle Proteolysis in Sepsis or Trauma

To the Editor: In two important articles in the March 10 issue of the Journal , Clowes et al. 1 and Baracos et al. 2 have provided evidence that one or more protein mediators may be responsible for the protein catabolic response to infection in skeletal muscle. Whether the circulating peptide is int...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 309; no. 8; pp. 494 - 495
Main Authors Moldawer, L L, Bistrian, B R, Sobrado, J, Blackburn, G L
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 25.08.1983
Subjects
Animals
Cyclooxygenase Inhibitors
Dietary Proteins - administration & dosage
Humans
Infection - metabolism
Interleukin-1 - physiology
Muscle Proteins - metabolism
Rats
Wounds and Injuries - metabolism
Online AccessGet full text

Cover

More Information
Summary:To the Editor: In two important articles in the March 10 issue of the Journal , Clowes et al. 1 and Baracos et al. 2 have provided evidence that one or more protein mediators may be responsible for the protein catabolic response to infection in skeletal muscle. Whether the circulating peptide is interleukin-1 (leukocyte pyrogen, endogenous pyrogen, or leukocyte endogenous mediator) or a 4000-dalton glycoprotein, the accompanying editorial by Beisel has emphasized the importance of these proteins as hormone-like mediators produced by phagocytic cells and responsible for signaling distant tissues about the presence of infection. 3 Both groups have recognized the potential benefit . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198308253090814