Novel indole containing thiazolidinedione derivatives as potent euglycemic and hypolipidaemic agents

Several thiazolidinediones having indol as heterocyclic moiety have been synthesized and evaluated for euglycemic properties. A few of them have been found to be superior to troglitazone. 5-[4-[2-(1-Indolyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione has been found to be an excellent euglycemic and...

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Published inBioorganic & medicinal chemistry letters Vol. 7; no. 7; pp. 785 - 788
Main Authors Lohray, Braj B., Bhushan, V., Rao, P.Bheema, Madhavan, G.R., Murali, N., Rao, K.Narasimha, Anantha Reddy, K., Rajesh, B.M., Ganpathy Reddy, P., Chakrabarti, R., Rajagopalan, R.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 08.04.1997
Elsevier
Subjects
Biological and medical sciences
General and cellular metabolism. Vitamins
Medical sciences
Pharmacology. Drug treatments
Sulfur nitrogen heterocycle
Five membered ring
Nitrogen heterocycle
Carbazole derivatives
Diabetes mellitus
Thiazole derivatives
Rodentia
Oral administration
Tricyclic compound
Cholesterol
Vertebrata
Hypoglycemic agent
Mammalia
Structure activity relation
Mouse
Animal
Indole derivatives
Chemical synthesis
Antilipemic agent
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Summary:Several thiazolidinediones having indol as heterocyclic moiety have been synthesized and evaluated for euglycemic properties. A few of them have been found to be superior to troglitazone. 5-[4-[2-(1-Indolyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione has been found to be an excellent euglycemic and hypolipidaemic agent.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00118-2