Lipid Metabolism in Inflammation and Immune Function

[...]therapeutic strategies and nutritional interventions that target lipid metabolism are promising approaches to mitigate inflammation and optimize immune function in obesity, cardiovascular disease, chronic metabolic and inflammatory disorders, autoimmunity, and pathogen defense [1,2]. Importantl...

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Published inNutrients Vol. 14; no. 7; p. 1414
Main Author Andersen, Catherine J.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.03.2022
MDPI
Subjects
Chronic illnesses
Humans
Immunity
Inflammation
Inflammation - metabolism
Lipid Metabolism
Lipids
Metabolites
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Summary:[...]therapeutic strategies and nutritional interventions that target lipid metabolism are promising approaches to mitigate inflammation and optimize immune function in obesity, cardiovascular disease, chronic metabolic and inflammatory disorders, autoimmunity, and pathogen defense [1,2]. Importantly, the authors further highlight findings from pivotal and recent clinical trials that investigated the beneficial effects of n-3 polyunsaturated fatty acids or Mediterranean-style dietary patterns on a wide range of health outcomes, including cardiovascular disease, obesity, maintenance of muscle strength with aging, chronic kidney disease, allergy, and depression. [4] characterized the differential effects of free, non-esterified saturated (palmitic acid), monounsaturated (oleic acid), n-3 polyunsaturated (α-linolenic, docosahexaenoic acid (DHA)) and n-6 polyunsaturated (γ-linolenic and arachidonic acid (AA)) fatty acids on inflammatory gene expression and H2O2 production in ex vivo peripheral blood mononuclear cells (PBMCs) isolated from subjects with metabolic syndrome. [...]infusion of 100% soybean oil resulted in increased plasma AA:
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu14071414