Thyroid Function at High Altitude

To the Editor: Our studies of plasma thyroxine-binding globulin concentrations 1 in subjects ascending to 5400 m showed rises similar to those reported by Mordes and colleagues (May 12, 1983, issue). 2 We have extended these observations by measurement of plasma levels of thyroxine-binding/prealbumi...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 310; no. 20; p. 1334
Main Authors Wright, A. D, Black, E. G, Fletcher, R. F, Bradwell, A. R
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 17.05.1984
Subjects
Altitude
Humans
Thyroid Gland - physiology
Thyroxine-Binding Proteins - analysis
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Summary:To the Editor: Our studies of plasma thyroxine-binding globulin concentrations 1 in subjects ascending to 5400 m showed rises similar to those reported by Mordes and colleagues (May 12, 1983, issue). 2 We have extended these observations by measurement of plasma levels of thyroxine-binding/prealbumin, using a radial-immunodiffusion method, in 20 normal subjects ascending to 5000 m for three days (Table 1). The concentrations of the binding proteins were not significantly affected by changes in plasma volume (mean packed-cell volume, 42.1 per cent at sea level and 40.5 per cent at 5000 m). The fall in the value of thyroxine-binding/prealbumin was similar in . . . No extract is available for articles shorter than 400 words.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198405173102022