Hyperceruloplasminemia in Hemochromatosis

To the Editor: We have measured the levels of ceruloplasmin in the serum of 15 patients with primary hemochromatosis, 20 of their asymptomatic relatives (parents, brothers and sisters, and children; eight families), and 20 controls. We found hyperceruloplasminemia both in the patients (56.9±24.1 mg...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 304; no. 17; p. 1047
Main Authors Borda, F, Uribarrena, R, Miranda, M P
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.04.1981
Subjects
Ceruloplasmin - analysis
Female
Hemochromatosis - blood
Humans
Male
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Summary:To the Editor: We have measured the levels of ceruloplasmin in the serum of 15 patients with primary hemochromatosis, 20 of their asymptomatic relatives (parents, brothers and sisters, and children; eight families), and 20 controls. We found hyperceruloplasminemia both in the patients (56.9±24.1 mg per 100 ml) and in their relatives (58.3±24.4 mg) as compared with the control group (38.4±13.1 mg) (P<0.01 and P<0.005, respectively). The patients with the least hepatic damage and normal prothrombin times were those who had the highest levels of ceruloplasmin. Although there was a direct correlation between the ceruloplasmin level and the prothrombin time, this . . . No extract is available for articles shorter than 400 words.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198104233041721