Syntheses of homoserine phosphate analogs as potential inhibitors of bacterial threonine synthase

The syntheses of five homoserine phosphate analogs ( 1–4, Z-5) are described. A brief summary of their potential to inhibit threonine synthase from Escherichia coli is given. The syntheses of five homoserine phosphate analogs are described. A brief summary of their potential to inhibit threonine syn...

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Published inBioorganic & medicinal chemistry letters Vol. 4; no. 2; pp. 273 - 278
Main Authors Harde, Christoph, Neff, Karl-Heinz, Nordhoff, Erhard, Gerbling, Klaus-Peter, Laber, Bernd, Pohlenz, Hans-Dieter
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 20.01.1994
Elsevier
Subjects
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Structure activity relation
Enzyme
Threonine synthase
Analog
Escherichia coli
Enzyme inhibitor
Bacteria
Lyases
Antibacterial agent
Chemical synthesis
Carbon-oxygen lyases
Enterobacteriaceae
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Summary:The syntheses of five homoserine phosphate analogs ( 1–4, Z-5) are described. A brief summary of their potential to inhibit threonine synthase from Escherichia coli is given. The syntheses of five homoserine phosphate analogs are described. A brief summary of their potential to inhibit threonine synthase from Escherichia coli is given.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80128-1