Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma

• Published in: Frontiers in bioscience Vol. 26; no. 4; pp. 692 - 705
• Main Authors: Tian, Ruyue, Zhao, Guiping, Zhou, Anni, Li, Huihui, Cao, Bangwei, Guo, Shuilong
• Format: Journal Article
• Language: English
• Published: Singapore IMR Press 01.01.2021
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - immunology; Databases, Genetic; Female; gene expression omnibus; Gene Expression Profiling; Gene Ontology; Humans; Middle Aged; Ovarian Neoplasms - genetics; Ovarian Neoplasms - immunology; ovarian serous adenocarcinoma; Prognosis; the cancer genome atlas; Tumor Microenvironment
• ISSN: 1093-9946; 2768-6701; 2768-6698; 1093-4715
• DOI: 10.2741/4913

Ovarian serous adenocarcinoma is one of the most common and fatal malignancies among women worldwide. The tumor microenvironment plays a critical role in tumor initiation, proliferation, and metastasis. Immune scores and stromal scores of the tumor microenvironment were determined using the ESTIMATE. Immune cell infiltration was assessed using TIMER and differentially expressed genes (DEGs) were determined using the R/Bioconductor package of edgeR. Survival analysis was carried out using a univariate Cox model and Kaplan-Meier survival, and gene functional information was obtained through Gene Ontology and KEGG pathway analysis. Survival analysis revealed 39 DEGs that significantly influenced the prognosis of ovarian serous adenocarcinoma patients and were correlated with immune cell abundance. Functional enrichment and protein-protein interaction network analyses further indicated that these genes are primarily involved in immune-related responses. Finally, we verified the prognostic value of these genes via GEO. The present results reveal the genes associated with the tumor microenvironment of ovarian adenocarcinoma, potentially providing prognostic information.