Synthesis and antibacterial studies of some novel isoxazoline derivatives

A series of 3-[3-(2,4-dichloro-5-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazol- 1-yl]-5-(substituted phenyl/2-thienyl)isoxazolines (4a-j) were prepared. The structures of the isoxazoline derivatives were confirmed on the bases of elemental analysis and spectral data. The compounds were screened f...

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Bibliographic Details
Published inJournal of the Serbian Chemical Society Vol. 72; no. 5; pp. 443 - 449
Main Authors Shah, Tejaskumar, Desai, Vikas
Format Journal Article
LanguageEnglish
Published Serbian Chemical Society 01.01.2007
Subjects
antibacterial activity
chalcone
heterocyclic synthesis
isoxazoline
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Summary:A series of 3-[3-(2,4-dichloro-5-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazol- 1-yl]-5-(substituted phenyl/2-thienyl)isoxazolines (4a-j) were prepared. The structures of the isoxazoline derivatives were confirmed on the bases of elemental analysis and spectral data. The compounds were screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Dobijena je serija 3-[3-(2,4-dihloro-5-fluorofenil)-5-(2-furil)-4,5-dihidro-1H-pirazol- 1-il]-5-(supstituisani fenil/2-tijenil)-izoksazolina (4a-j). Strukture izoksazolinskih derivata su potvrdjene na osnovu elementalne analize i spektralnih podataka. Ispitana je antibakterijska aktivnost ovih jedinjenja prema gram-pozitivnim i gram-negativnim bakterijama.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC0705443S