Preparation of protein-loaded-PLGA microspheres by an emulsion/solvent evaporation process employing LTCC micromixers

• Published in: Powder technology Vol. 190; no. 1; pp. 107 - 111
• Main Authors: Ribeiro-Costa, R.M., Cunha, Márcio Rodrigues da, Gongora-Rubio, M.R., Michaluart-Júnior, P., Ré, M.I.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 05.03.2009; Elsevier
• Subjects: Applied sciences; Chemical engineering; Exact sciences and technology; LTCC; Microchannel; Micromixer; Microspheres; Miscellaneous; Protein release; Solid-solid systems; Microspheres; LTCC; Micromixer; Microchannel; Protein release; Fluid mechanics; Microsphere; Evaporation; Modeling; Emulsion; Micromixing; Preparation; Production; Ceramic materials; Microfluidics; Low temperature
• ISSN: 0032-5910; 1873-328X
• DOI: 10.1016/j.powtec.2008.04.093

This study presents the possibilities offered by microfluidic structures for the production of polymeric microspheres, using a process based upon the production of an emulsion. LTCC (Low Temperature Co-fired Ceramics) micromixers have been used for the preparation of polymeric microspheres. The effect of the geometry of the micromixers has been studied, with a specific focus on the size of the microspheres, as well as the control release properties of a model protein loaded within these microspheres. This study presents the possibilities offered by LTCC (Low Temperature Co-fired Ceramics) micromixers for the production of polymeric microspheres, using a process based upon the production of an emulsion. The effect of the geometry of the micromixers has been studied with a specific focus on the particle size and the control release properties of the microspheres. ▪