Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules

Multifunctional scaffolds with dual release of small molecular drugs and biomacromolecules have potential in many applications such as cancer postoperative care, which require appropriate administration of anticancer drugs and biomacromolecules in a spatiotemporal manner. Herein, a systematic invest...

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Bibliographic Details
Published inMRS communications Vol. 9; no. 1; pp. 413 - 420
Main Authors Zhou, Yu, Zhao, Qilong, Tsai, Natasha L.Y., Wang, Min
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 01.03.2019
Springer International Publishing
Subjects
Biomaterials
Biomedical materials
Cancer
Cancer therapies
Characterization and Evaluation of Materials
Drug delivery systems
Drugs
Efficiency
Growth factors
Materials Engineering
Materials Science
Methods
Nanotechnology
Polymer Sciences
Polymers
Research Letter
Research Letters
Scaffolds
Tissue engineering
United States > US
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Summary:Multifunctional scaffolds with dual release of small molecular drugs and biomacromolecules have potential in many applications such as cancer postoperative care, which require appropriate administration of anticancer drugs and biomacromolecules in a spatiotemporal manner. Herein, a systematic investigation into the dual release of anticancer drugs and biomacromolecules from the bicomponent nanofibrous scaffolds is performed. Their release behavior is affected by different fabrication techniques and different polymers used. We show that the bicomponent scaffold fabricated by dual-source dual-power emulsion electrospinning enables dual release of anticancer drugs and biomacromolecules in a controlled manner, holding promise for combinational cancer postoperative care.
ISSN:2159-6859
2159-6867
DOI:10.1557/mrc.2019.23