Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis

Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency o...

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Bibliographic Details
Published inHuman immunology Vol. 63; no. 4; pp. 281 - 285
Main Authors de Jong, Brigit A, Westendorp, Rudi G J, Eskdale, Joyce, Uitdehaag, Bernard M J, Huizinga, Tom W J
Format Journal Article
LanguageEnglish
Published United States 01.04.2002
Subjects
Adult
Disease Susceptibility
Female
HLA-DR2 Antigen - immunology
Humans
Interleukin-10 - biosynthesis
Interleukin-10 - genetics
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive - genetics
Multiple Sclerosis, Chronic Progressive - immunology
Multiple Sclerosis, Relapsing-Remitting - genetics
Multiple Sclerosis, Relapsing-Remitting - immunology
Polymorphism, Genetic
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Summary:Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.
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ISSN:0198-8859
DOI:10.1016/S0198-8859(02)00369-5