Conformational analysis of δ-lactams

δ-lactams substituted at C-5 by an oxygen atom exist, in solution principally, in the axial conformation. This axial preferred form is also present in the solid state. It has been observed that C-5 oxygen substituted lactams exist, in solution principally, in the axial conformation due to the attrac...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron Vol. 50; no. 27; pp. 7947 - 7956
Main Authors Boudreault, Nicolas, G. Ball, Richard, Bayly, Christopher, A. Bernstein, Michael, Leblanc, Yves
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 1994
Elsevier
Subjects
Atomic and molecular physics
Chemistry
Chemistry, Organic
Conformation (statistics and dynamics)
Exact sciences and technology
Macromolecules and polymer molecules
Physical Sciences
Physics
Science & Technology
Studies of special atoms, molecules and their ions; clusters
BIS(2,2,2-TRICHLOROETHYL) AZODICARBOXYLATE
GLYCALS
GLUTAMIC-ACID
CYCLO-ADDITION REACTION
COUPLING-CONSTANTS
KARPLUS EQUATION
Hydrogen 1
Molecular structure
Nitrogen heterocycle
Chemical preparation
Conformational analysis
Lactams
NMR spectra
Experimental study
Organic compounds
Online AccessGet full text

Cover

More Information
Summary:δ-lactams substituted at C-5 by an oxygen atom exist, in solution principally, in the axial conformation. This axial preferred form is also present in the solid state. It has been observed that C-5 oxygen substituted lactams exist, in solution principally, in the axial conformation due to the attractive gauche effect. This form is also present in the solid state.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(01)85279-0