A NEW PROCESS FOR THE ENANTIOSELECTIVE SYNTHESIS OF CHIRAL ALPHA-ARYLOXY AND ALPHA-HYDROXY ACIDS

Chiral trichloromethyl carbinols 3, readily available by catalytic enantioselective reduction of trichloromethyl ketones, are converted with inversion of configuration into chiral alpha-aryloxy and alpha-hydroxy carboxylic acid derivatives.

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Bibliographic Details
Published inTetrahedron letters Vol. 33; no. 24; pp. 3431 - 3434
Main Authors COREY, EJ, LINK, JO
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 09.06.1992
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ALCOHOLS
KETONES
CATALYST
REDUCTION
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Summary:Chiral trichloromethyl carbinols 3, readily available by catalytic enantioselective reduction of trichloromethyl ketones, are converted with inversion of configuration into chiral alpha-aryloxy and alpha-hydroxy carboxylic acid derivatives.
ISSN:0040-4039
DOI:10.1016/S0040-4039(00)92655-8