Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model

• Published in: Physiological measurement Vol. 40; no. 5; p. 054002
• Main Authors: Stowe, Symon, Boyle, Alistair, Sage, Michaël, See, Wendy, Praud, Jean-Paul, Fortin-Pellerin, Étienne, Adler, Andy
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 04.06.2019
• Subjects: Animals; Electric Impedance; electrical impedance tomography; Lung - physiology; lung perfusion; Models, Animal; Perfusion; Sheep; Tomography; ventilation
• ISSN: 0967-3334; 1361-6579; 1361-6579
• DOI: 10.1088/1361-6579/ab1794

Objective: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper systematically compares filtering-based perfusion estimates and bolus injection methods to determine to which degree they are related. Approach: EIT data was recorded on seven mechanically ventilated newborn lambs in which ventilation distribution was varied through changes in posture between prone, supine, left- and right-lateral positions. Perfusion images were calculated using frequency filtering and ensemble averaging during both ventilation and apnoea time segments for each posture to compare against contrast agent-based methods using Jaccard distance score. Main results: Using bolus-based EIT measures of lung perfusion as the reference frequency filtering techniques performed better than ensemble averaging and both techniques performed equally well across apnoea and ventilation data segments. Significance: Our results indicate the potential for use of filtering-based EIT measures of heart-frequency activity as a non-invasive proxy for contrast agent injection-based measures of lung perfusion.