α-Tocopherol acetate-loaded chitosan microparticles: Stability during spray drying process, photostability and swelling evaluation

• Published in: Journal of drug delivery science and technology Vol. 30; pp. 220 - 224
• Main Authors: Pereira, Gabriela Garrastazu, Detoni, Cassia Britto, da Silva, Tiago Lima, Colomé, Letícia Marques, Pohlmann, Adriana Raffin, Guterres, Silvia Stanisçuaski
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2015
• Subjects: Aloe vera; Alpha-tocopherol acetate; Microparticles; Photostability and swelling; Alpha-tocopherol acetate; Photostability and swelling; Microparticles
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2015.10.018

Chitosan/α-tocopherol acetate/Aloe vera microparticles were prepared by spray drying and characterized concerning their size, drug content, chemical integrity and photostability. The particles were spherical, with a rough surface, micrometric (D[4,3] = 9.59 μm), unimodal and polydisperse (SPAN of 1.12). The final α-tocopherol acetate concentration in the powder was 91% of the expected amount. FTIR analyses confirmed that α-tocopherol acetate dose not suffer oxidation during the spray drying process. Furthermore, α-tocopherol acetate photostability in the microparticles was evaluated for 7 days in a UVC light chamber. The microparticles were capable of maintaining the concentration of α-tocopherol acetate for a longer time than a commercially available pulverized form of α-tocopherol acetate. When added to a hydrophilic gel, particles tend to partially swell and form a second population of larger particles. The second population formed was less representative. [Display omitted]