The unprecedented iridal lactone and adducts of spiroiridal and isoflavonoid from Belamcanda chinensis

Five novel iridal-type triterpenoid derivatives, including three unprecedented adducts of spiroiridal and isoflavonoid, named belamcandanins A–C ( 1–3 ), one unprecedented iridal lactone, named belamcanolide A ( 4 ), and one new and rare iridal epoxide, named belamcanoxide A ( 5 ), have been isolate...

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Bibliographic Details
Published inRSC advances Vol. 7; no. 33; pp. 20160 - 20166
Main Authors Ni, Gang, Shi, Guo-Ru, Li, Jia-Yuan, Yu, De-Quan
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 2017
Subjects
Adducts
Biotechnology
NMR
Nuclear magnetic resonance
Toxicity
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Summary:Five novel iridal-type triterpenoid derivatives, including three unprecedented adducts of spiroiridal and isoflavonoid, named belamcandanins A–C ( 1–3 ), one unprecedented iridal lactone, named belamcanolide A ( 4 ), and one new and rare iridal epoxide, named belamcanoxide A ( 5 ), have been isolated from the rhizomes of Belamcanda chinensis , along with five known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–3 represent the first meroterpenoids composed of an isoflavonoid linked to a spiroiridal-triterpenoid. To the best of our knowledge, compound 4 is the first example of 5/6-fused bicyclic iridal lactone. Compounds 1–8 were evaluated for their in vitro cytotoxicity against five tumor cell lines. Among them, compounds 5–8 showed moderate cytotoxic activities against five cancer cell lines with IC 50 values from 3.26 to 8.63 μM.
ISSN:2046-2069
2046-2069
DOI:10.1039/C7RA00614D