Plasma intestinal fatty acid binding protein in neonates with necrotizing entercolitis: A pilot study

• Published in: Journal of pediatric surgery Vol. 34; no. 10; pp. 1453 - 1457
• Main Authors: Edelson, Mary B., Sonnino, Roberta E., Bagwell, Charles E., Lieberman, Joshua M., Marks, William H., Rozycki, Henry J.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.10.1999; Elsevier
• Subjects: Biological and medical sciences; Gastroenterology. Liver. Pancreas. Abdomen; Medical sciences; Other diseases. Semiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Necrotizing enterocolitis; diagnosis; staging; Human; Plasma; Binding protein; Concentration factor; Newborn; Biological marker; Digestive diseases; Intestinal disease; Severity score; Diagnosis; Fatty acids
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/S0022-3468(99)90102-1

Background/Purpose: Intestinal fatty acid-binding protein (IFABP) is found within cells at the tip of the intestinal, villi, an area commonly injured when necrotizing enterocolitis (NEC) occurs. This study was undertaken to determine if measuring IFABP concentrations in the bloodstream early in the course of NEC would differentiate patients by severity before clinical findings made it clear who had stage 3 NEC and who had milder stages. Methods: Three plasma samples from newborn infants evaluated for NEC were obtained at symptom onset and after 8 and 24 hours. IFABP concentration was measured by radioimmunoassay. Infants were classified by the final and most severe stage of NEC, and IFABP levels were compared between groups at each sampling. Results: IFABP was detectable in blood samples from all 7 infants with stage 3 NEC compared with 3 of 24 with stages 1 or 2 NEC. Elevated plasma IFABP concentrations were detectable before clinical staging could be made in 5 of the 7 subjects with stage 3 NEC. Conclusion: IFABP may be a specific marker for early identification of severe NEC.