Analytical techniques for solid-phase organic and combinatorial synthesis

In the developmental phase leading to solid-phase library generation, it is essential that reactions can be efficiently and readily optimized and quantified, and this requires reliable and sensitive techniques for the analysis of solid-phase reactions. The exploding interest in different types of so...

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Bibliographic Details
Published inDrug discovery today Vol. 2; no. 3; pp. 102 - 109
Main Authors Egner, Bryan J., Bradley, Mark
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.1997
Elsevier Science
Subjects
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Drug
Fourier transformation
Colorimetry
Matrix effect
NMR spectrometry
Review
Laser desorption
Magic angle
Infrared spectrometry
Investigation method
Photoionization
Time of flight method
Qualitative analysis
Solid phase
Chemical synthesis
Mass spectrometry
Quantitative analysis
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Summary:In the developmental phase leading to solid-phase library generation, it is essential that reactions can be efficiently and readily optimized and quantified, and this requires reliable and sensitive techniques for the analysis of solid-phase reactions. The exploding interest in different types of solid-phase chemistry is placing increased demands on the reliability, diversity and sensitivity of such analytical methods. The authors describe the most exciting developments of the past 4–5 years.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(97)01003-9