Impact of the inhibition of proteins activities and the chemical aspect of polyphenols-proteins interactions

• Published in: PharmaNutrition Vol. 7; p. 100142
• Main Authors: Adrar, Nassim Salem, Madani, Khodir, Adrar, Sabah
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2019
• Subjects: alpha-amylase; alpha-glucosidase; amine oxidase (flavin-containing); antioxidants; astringency; atherosclerosis; bioavailability; Chemical aspect; Chemical binding; cholera toxin; coenzyme A; cytochrome P-450; diet; enterotoxins; functional foods; Hepatitis C virus; hepatoprotective effect; hydrogen bonding; hydrophobic bonding; Impact; Inhibition; laminin; leukotoxins; metalloproteinases; microbial enzymes; nutritive value; phospholipase A2; Polyphenol; polyphenols; Protein; public health; RNA-directed DNA polymerase; secondary metabolites; transcription factor NF-kappa B; PRPs; Impact; EGCG; PLA2; CYP3A4; Protein; NF-κB; Polyphenol; Nrf2; LDL; HMG-CoA reductase; Chemical aspect; Keap1; MAO; HCV; Chemical binding; Inhibition; MMP-2 and MMP-9; 67LR
• ISSN: 2213-4344; 2213-4344
• DOI: 10.1016/j.phanu.2019.100142

[Display omitted] •Polyphenol-protein interaction depends on the types of protein and polyphenol.•Chemical bindings are primarily hydrophobic interactions and hydrogen bonds.•Astringency may be caused by the polyphenol-protein interactions.•Polyphenols have several very interesting biological activities.•Various protein are the targets of differents polyphenols. The good nutritional value and the interesting biological activities of the plant-based nutraceuticals are primarily due to the polyphenols. These latter are among the most important and extensively studied plant secondary metabolites and their interaction with proteins is the subject of considerable researches. This interaction is fundamental to the rational design of functional foods as well as to improve the bioavailability and the biofunctionality of the polyphenols. In this work, we emphasized that the types of proteins and polyphenols influence this interaction and chemical bindings are primarily hydrophobic interactions and hydrogen bonds. We highlighted further the anti- atherosclerosis, anti-inflammatory, anti-diabetic, neuro-protective, antioxidant, anti-proliferative, antimicrobial and the hepatoprotective activities of the polyphenols. We also mentioned that astringency and these health benefits may be caused by the interaction with proteins, and that the proteins targeted by polyphenols are: Kelch-like ECH-associated protein 1, extracellular microbial enzymes, phospholipase A2, monoamine oxidase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, laminin receptor, hepatitis C virus NS3 protease, virus-encoded integrase, retroviral reverse transcriptase, leukotoxin, enterotoxin, cholera toxin, α-glucosidase, α-amylase, pro-oxidant enzymes, nuclear factor kappa B, cytochrome P450, metalloproteinases, β- and γ-secretases. A healthy, balanced diet and rich in polyphenols can prevent and even control the major public health problems worldwide.