NOVEL METHODS FOR SYNTHESES OF SUBSTITUTED OXAZOLES BY CYCLIZATION OF VINYL BROMIDES

Several methods for converting vinyl bromides and vinyl dibromides to oxazoles are described. Cyclization of vinyl bromide 6 with cesium carbonate in dioxane forms oxazole 7 while 6 is converted to the corresponding bromooxazole 12 by treatment with CuBr2/DBU.

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Bibliographic Details
Published inTetrahedron letters Vol. 33; no. 51; pp. 7835 - 7838
Main Authors DAS, J, REID, JA, KRONENTHAL, DR, SINGH, J, PANSEGRAU, PD, MUELLER, RH
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 15.12.1992
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Several methods for converting vinyl bromides and vinyl dibromides to oxazoles are described. Cyclization of vinyl bromide 6 with cesium carbonate in dioxane forms oxazole 7 while 6 is converted to the corresponding bromooxazole 12 by treatment with CuBr2/DBU.
ISSN:0040-4039
DOI:10.1016/S0040-4039(00)74756-3