White matter microstructure mediates the pairwise relationship between childhood maltreatment, microRNA-9, and the severity of major depressive disorder

To describe the gene–behavioral–brain relationship, diffusion tensor imaging (DTI) was used to quantitatively assess WM, offering information about axonal size, myelination, and orientation. A previous study indicated that CM affects miR-9 levels, potentially affecting MDD. miR-9 alterations in stre...

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Published inChinese medical journal Vol. 137; no. 17; pp. 2140 - 2142
Main Authors Liu, Xinyi, He, Cancan, Bai, Ying, Fan, Dandan, Zang, Feifei, Zhang, Hongxing, Zhang, Haisan, Yao, Honghong, Zhang, Zhijun, Xie, Chunming
Format Journal Article
LanguageEnglish
Published China Lippincott Williams & Wilkins Ovid Technologies 05.09.2024
Lippincott Williams & Wilkins
Wolters Kluwer
Subjects
Adult
Anxiety
Brain
Child Abuse - psychology
Correspondence
Depressive Disorder, Major - pathology
Female
Humans
Male
Mental depression
MicroRNAs
MicroRNAs - genetics
Regression analysis
White Matter - diagnostic imaging
White Matter - pathology
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Summary:To describe the gene–behavioral–brain relationship, diffusion tensor imaging (DTI) was used to quantitatively assess WM, offering information about axonal size, myelination, and orientation. A previous study indicated that CM affects miR-9 levels, potentially affecting MDD. miR-9 alterations in stress models affect MDD symptoms. [...]this study proposes a two-step mediation model, testing the effects of interest. Tract-based spatial statistics (TBSS) was employed for voxelwise statistical analysis of DTI data, involving registration, skeletonization, and projection onto the WM skeleton to analyze fractional anisotropy (FA). [...]through multiple linear regression analysis, the main effect of CM on brain networks was determined [Supplementary Figure 2A, http://links.lww.com/CM9/C61].
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/CM9.0000000000003188