White matter microstructure mediates the pairwise relationship between childhood maltreatment, microRNA-9, and the severity of major depressive disorder
To describe the gene–behavioral–brain relationship, diffusion tensor imaging (DTI) was used to quantitatively assess WM, offering information about axonal size, myelination, and orientation. A previous study indicated that CM affects miR-9 levels, potentially affecting MDD. miR-9 alterations in stre...
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Published in | Chinese medical journal Vol. 137; no. 17; pp. 2140 - 2142 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
China
Lippincott Williams & Wilkins Ovid Technologies
05.09.2024
Lippincott Williams & Wilkins Wolters Kluwer |
Subjects | |
Online Access | Get full text |
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Summary: | To describe the gene–behavioral–brain relationship, diffusion tensor imaging (DTI) was used to quantitatively assess WM, offering information about axonal size, myelination, and orientation. A previous study indicated that CM affects miR-9 levels, potentially affecting MDD. miR-9 alterations in stress models affect MDD symptoms. [...]this study proposes a two-step mediation model, testing the effects of interest. Tract-based spatial statistics (TBSS) was employed for voxelwise statistical analysis of DTI data, involving registration, skeletonization, and projection onto the WM skeleton to analyze fractional anisotropy (FA). [...]through multiple linear regression analysis, the main effect of CM on brain networks was determined [Supplementary Figure 2A, http://links.lww.com/CM9/C61]. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0366-6999 2542-5641 2542-5641 |
DOI: | 10.1097/CM9.0000000000003188 |