Alterations in neural oscillations related to working memory deficit in temporal lobe epilepsy

•Theta oscillations were altered during a working memory task in patients with TLE.•Reduced theta power in the encoding phase was associated with longer reaction time.•Alterations in theta power are related to working memory deficits in patients with TLE. Working memory (WM) is critical for higher l...

Full description

Saved in:
Bibliographic Details
Published inEpilepsy & behavior Vol. 121; p. 108063
Main Authors Pan, Liping, Guo, Dandan, Wang, Jiajing, Hao, Yuhan, Zhang, Lulin, Qin, Xiao, Song, Yijun
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.08.2021
Subjects
Encoding
Temporal lobe epilepsy
Theta oscillation
Working memory deficit
RT
F
tACS
STFT
PFC
TLE
AEDs
Cp
O
DMTS task
ANOVA
RD group
Theta oscillation
WM
LSD
PSD
ACC
EEG
Lt
MD group
ED group
Encoding
Working memory deficit
Con group
Temporal lobe epilepsy
SEM
Online AccessGet full text

Cover

More Information
Summary:•Theta oscillations were altered during a working memory task in patients with TLE.•Reduced theta power in the encoding phase was associated with longer reaction time.•Alterations in theta power are related to working memory deficits in patients with TLE. Working memory (WM) is critical for higher level cognition, but the underlying neural mechanisms are not fully understood. Impaired WM affects routine daily activities and is observed in patients with temporal lobe epilepsy (TLE). This study investigated neural oscillations associated with different WM phases, to determine the specific neural activity linked with the phases of WM impairment. Patients with TLE (n = 52) and healthy volunteers (n = 35) completed a WM task, during which 34-channel electroencephalogram signals were recorded. Characteristic neural oscillation patterns during each WM phase were compared between the 2 groups. Patients with TLE showed decreased theta power during the encoding phase of WM, which was associated with reduced accuracy in the WM task. Altered theta power in the frontal region of the brain during the encoding phase was associated with a longer reaction time. Alterations in theta oscillation are related to WM impairment in patients with TLE and may serve as an early marker for evaluating WM deficits. This study provides an early marker for evaluating WM deficits in TLE.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2021.108063