Phenylacetyl group as enzyme-cleavable aminoprotection of purine nucleosides

N 6-Phenylacetyl-2′-deoxyadenosine and N 2-Phenylacetyl-2′-deoxyguanosine are readily deprotected in reactions catalyzed by free and immobilized penicillin amidase at pH 7.8 and 25°C. N 6-Phenylacetyl-2′-deoxyadenosine and N 2-phenylacetyl-2′-deoxyguanosine are readily deprotected in reactions catal...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 3; no. 12; pp. 2781 - 2784
Main Authors Dineva, M.A., Galunsky, B., Kasche, V., Petkov, D.D.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.12.1993
Elsevier
Subjects
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
N-phenylacletyl protection
nucleosides
nucleotide synthesis
penicillin amidase
N-phenylacletyl protection
nucleosides
penicillin amidase
nucleotide synthesis
Hydrolysis
Protecting group
Penicillin amidase
Purine nucleoside
Enzyme
Free form
Deprotection
Hydrolases
Immobilized enzyme
Enzymatic reaction
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Summary:N 6-Phenylacetyl-2′-deoxyadenosine and N 2-Phenylacetyl-2′-deoxyguanosine are readily deprotected in reactions catalyzed by free and immobilized penicillin amidase at pH 7.8 and 25°C. N 6-Phenylacetyl-2′-deoxyadenosine and N 2-phenylacetyl-2′-deoxyguanosine are readily deprotected in reactions catalyzed by free and immobilized penicillin amidase at pH 7.8 and 25°C
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80763-0