Derivatives of 3-cyano-6-phenyl-4-(3`-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity

• Published in: European journal of medicinal chemistry Vol. 34; no. 4; pp. 301 - 310
• Main Authors: Krauze, Aivars, Ģērmane, Skaidrite, Eberlin |nE š, Ojārs, Šturms, Igors, Klusā, Vija, Duburs, Gunárs
• Format: Journal Article
• Language: English
• Published: PARIS CEDEX 15 Elsevier Masson SAS 01.04.1999; Elsevier
• Subjects: 1,2-dihydro-2-thioxopyridine-3-carbonitrile; antiamnesic agent; Biological and medical sciences; bispyridyldisulfide; Chemistry, Medicinal; Life Sciences & Biomedicine; Medical sciences; Neuropharmacology; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Science & Technology; thieno[2,3-b]pyridine; 1,2-dihydro-2-thioxopyridine-3-carbonitrile; thieno[2,3-b]pyridine; bispyridyldisulfide; antiamnesic agent; CARDIOVASCULAR ACTIVITY; AMINES; BIOLOGICAL-ACTIVITY; ANTIANAPHYLACTIC ACTIVITY; POTENTIAL CARDIOTONIC AGENTS; Sulfur nitrogen heterocycle; Neurotropic; Intraperitoneal administration; Nitrile; Rat; CNS stimulant; Nitrogen heterocycle; Psychotropic; Toxicity; Rodentia; Oral administration; Organic sulfide; Pyridine derivatives; Vertebrata; Organic disulfide; Mammalia; Structure activity relation; Mouse; Animal; Nootropic agent; Bicyclic compound; Amnesia; Chemical synthesis
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/S0223-5234(99)80081-6

3-Cyano-6-phenyl-4-(3`-pyridyl)pyridine-2(1H)-thione, the related 2,2`-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD 50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05–0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg.