Antifungal activity of toothpastes against oral Candida isolates

• Published in: Journal de mycologie médicale Vol. 18; no. 3; pp. 141 - 146
• Main Authors: Yigit, N., Aktas, E., Ayyildiz, A.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier SAS 01.09.2008; Masson
• Subjects: Activité antifongique; Antifungal activity; Biological and medical sciences; Candida; Dentifrice; Fundamental and applied biological sciences. Psychology; Infectious diseases; Medical sciences; Microbiology; Miscellaneous; Mycology; Mycoses; Toothpastes; Dentifrice; Antifungal activity; Toothpastes; Candida; Activité antifongique; Fungi; Infection; Antifungal agent; Candidiasis; Yeast; Mycosis; Microbiology; Mycology; Isolate; Fungi Imperfecti
• ISSN: 1156-5233; 1773-0449
• DOI: 10.1016/j.mycmed.2008.06.003

Many types of toothpaste have been formulated over recent years to contain antimicrobial compounds with the aim of preventing or reducing plaque, calculus, gingivial inflammation or dental caries. Different brands have their own composition and concentration of ingredients for their efficacy. In this study, the anticandidal activity of six different toothpastes containing the following active ingredients: sodium fluoride, sodium monofluorophosphate, triclosan and herbal compounds were investigated against eight Candida species [ Candida glabrata ( n = 35), Candida albicans ( n = 25), Candida krusei ( n = 10), Candida tropicalis ( n = 9), Candida pseudotropicalis ( n = 7), Geotrichum candidum ( n = 7), Candida lipolytica ( n = 5), and Candida lusitaniae ( n = 4)], isolated from oral cavities and denture using the agar-diffusion test. Five toothpastes were effective in inhibiting the growth of all Candida species, while one toothpaste was not effective against C. tropicalis, C. pseudotropicalis and C. lusitaniae. The herbal toothpaste exhibited good antifungal activity against all Candida species. Récemment, plusieurs sortes de dentifrices contenant des substances antimicrobiennes ont été mises sur le marché pour prévenir ou réduire la plaque dentaire, l’inflammation gingivale ou les caries dentaires. Chaque marque possède sa propre composition, en vue de son efficacité. Le but de ce travail est d’analyser, par la technique de diffusion en gélose, l’activité antifongique de six dentifrices dont les principaux composés actifs sont le fluorure de sodium, le monofluorophosphate de sodium, le triclosan et diverses subtances végétales contre huit espèces de levures : Candida glabrata ( n = 35), Candida albicans ( n = 25), Candida krusei ( n = 10), Candida tropicalis ( n = 9), Candida pseudotropicalis ( n = 7), Geotrichum candidum ( n = 7), Candida lipolytica ( n = 5) et Candida lusitaniae ( n = 4), isolées de la cavité buccale et de prothèses dentaires. On observe qu’un dentifrice est inefficace contre C. tropicalis, C. pseudotropicalis et C. lusitaniae, alors que les cinq autres inhibent la croissance des différentes souches testées. Le dentifrice contenant des substances végétales a montré la meilleure activité antifongique contre toutes les espéces testées.