A Case of Successful Treatment of Postprandial Syncope with Combined Use of Amezinium Metilsulfate and Dihydroergotamine Mesylate

• Published in: Nihon Rōnen Igakkai zasshi Vol. 36; no. 7; pp. 499 - 502
• Main Authors: Kondo, Akira, Adachi, Noriko, Hayashi, Kyoichi
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japan Geriatrics Society 1999
• Subjects: Aged; Aged, 80 and over; amezinium metilsulfate; Dihydroergotamine - administration & dosage; dihydroergotamine mesylate; Drug Therapy, Combination; Eating; Humans; Male; postprandial hypotension; Pyridazines - administration & dosage; Sympathomimetics - administration & dosage; syncope; Syncope - drug therapy; Syncope - etiology; therapy; Vasoconstrictor Agents - administration & dosage
• ISSN: 0300-9173
• DOI: 10.3143/geriatrics.36.499

An 86-year-old man, with a history of old cerebral hemorrhage, experienced repeated syncope after the meal. The blood pressure significantly decreased at the onset of syncope, and postprandial hypotension (PPH) was diagnosed. In order to treat the syncope, we administered midodrine hydrochloride, amezinium metilsulfate and dihydroergotamine mesylate. However, each of these drugs failed to prevent PPH and the syncope persisted. Then we administered a combination of amezinium metilsulfate and dihydroergotamine mesylate. This led to the disappearance of the syncope together with PPH. Combined use of these drugs should be further evaluated in the elderly patients with PPH.