Small molecule delivery using carbon nano-test-tubes

A dye, as a model for small molecular drug, was inserted into carbon nano test tubes (35 nm in diameter, 4.5 μm in length) synthesized using nanochannels of an anodic aluminum oxide film as a template, and the open mouths of the test tubes were sealed by polystyrene polymer. The resulting test tubes...

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Bibliographic Details
Published inCarbon (New York) Vol. 46; no. 10; pp. 1361 - 1363
Main Authors Ittisanronnachai, Somlak, Orikasa, Hironori, Inokuma, Nobuhiro, Uozu, Yoshihiro, Kyotani, Takashi
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.08.2008
Elsevier Science
Subjects
Cross-disciplinary physics: materials science; rheology
Exact sciences and technology
Fullerenes and related materials; diamonds, graphite
Materials science
Physics
Specific materials
Water
Drugs
Aluminium oxide
Dyes
Films
Polystyrene
Carbon
Template
Cavities
Potentials
Models
Polymers
Diameter
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Summary:A dye, as a model for small molecular drug, was inserted into carbon nano test tubes (35 nm in diameter, 4.5 μm in length) synthesized using nanochannels of an anodic aluminum oxide film as a template, and the open mouths of the test tubes were sealed by polystyrene polymer. The resulting test tubes are dispersible in water, and the dye remains in the cavities because of the sealing. When the polymer-plug was dissolved by putting the test tubes into good solvents for polystyrene, the dye diffused out from the tube cavities. This study demonstrated the potential use of the test tubes as nano-sized carriers for drug and gene delivery.
ISSN:0008-6223
1873-3891
DOI:10.1016/j.carbon.2008.05.013