Effect of ion complexants on the iontophoresis of salbutamol

Small inorganic ions in transdermal systems can competitively reduce the iontophoretic delivery of the target drug. Crown ether sequesters Na + and its inclusion into salbutamol sulphate solutions (containing varying amounts of NaCl) produced a small increase in salbutamol flux. PEG 400, which has b...

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Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 167; no. 1; pp. 229 - 231
Main Authors Degim, I.Tuncer, Pugh, W.John, Hadgraft, Jonathan
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.06.1998
Elsevier
Subjects
Biological and medical sciences
Complexation
Crown ether
Iontophoresis
Medical sciences
Pharmacology. Drug treatments
Polyethylene glycol
Respiratory system
Salbutamol
Crown ether
Iontophoresis
Complexation
Salbutamol
Polyethylene glycol
Human
Transdermal system
Ether
Crown compound
Ions
Bioavailability
Ethylene oxide polymer
Sodium ion
Chelating agent
Skin
Pharmacokinetics
Release
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Summary:Small inorganic ions in transdermal systems can competitively reduce the iontophoretic delivery of the target drug. Crown ether sequesters Na + and its inclusion into salbutamol sulphate solutions (containing varying amounts of NaCl) produced a small increase in salbutamol flux. PEG 400, which has been reported to interact with cations such as Na +, caused a slight decrease in flux. Possibly any enhancement is outweighed by complexation of PEG with salbutamol cations and/or the increase in vehicle viscosity.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(98)00108-2